200716483R : BMC Biologie des maladies cardiovasculaires
- Unité de recherche
Adresse : Inserm U1034 -1 AVENUE DE MAGELLAN – Entrée par l’hôpital Haut-Lévêque 33604 PESSAC
Descriptif :
Clinical and basic research demonstrates that the endothelium plays a crucial role in mediating homeostasis and is involved in virtually every disease, either as a primary determinant of pathophysiology or as a victim of collateral damage. The endothelium is involved in the maintenance of normal organs and vascular structure and function. It may be thought as an organ by itself. Following its abnormalities in function would provide a tremendous opportunity to inform about the status of the disease progression. As it is widely distributed and easily accessible, it may be regarded as critical target in the fight against some cardio-neuro-vascular diseases.
Our project aims to improve endothelium knowledge, to understand how endothelium interacts with its microenvironment, to use it as a early marker of pathological conditions and to treat its dysfunction.
Wnt/Frizzled, Hedgehog and JAK2 signaling pathways are specifically studied in the endothelial dysfunction, in following different pathological settings: Role of endothelial cells in thrombosis – example of myeloproliferative neoplasms; Role of endothelial dysfunction in heart failure with preserved ejection fraction
Role of endothelial dysfunction in critical hind limb ischemia
Endothelial cells, blood-brain barrier dysfunction in cerebrovascular disease; Retinopathy and vascular lesions
Ecole(s) doctorale(s) de rattachement :
non renseignée
Rattachée au(x) thème(s) de recherche suivant(s):
non renseigné
Liens avec d'autres structures :
Aucun
Aucun
Contact: thierry.couffinhal@inserm.fr et christelle.boulle@inserm.fr
Année de création : 2007
Site ESR :
- Convention de coordination en Nouvelle-Aquitaine, depuis le 17/05/2020
Classement scientifique ERC :
non renseigné.
Domaine scientifique :
- 5 : Biologie, médecine et santé 2007
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INSERM
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Institut national de la sante et de la recherche medicale
(U 1034)
(établissement tutelle à partir de 2011) |
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BORDEAUX
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Université de Bordeaux
(UMR_S 1034)
(établissement tutelle à partir de 2014) |
Etablissement référent |
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Filiation
Structure(s) mère(s) :- 199915752F - ATHEROSCLEROSE : DETERMINISME CELLULAIRE ET MOLECULAIRE - CONSEQUENCES FONCTIONNELLES (éclatement)
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Libellé(s) de structure
- 06/10/2011 : ADAPTATION CARDIOVASCULAIRE À L'ISCHÉMIE
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Label et Numéro d'établissement
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14/04/2015 : UMR_S 1034
BORDEAUX - Université de Bordeaux (UMR_S 1034) -
16/02/2015 : U 1034
BORDEAUX - Université de Bordeaux (UMR_S 1034) -
06/10/2011 : U 1034
INSERM - Institut national de la sante et de la recherche medicale (U 1034)
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14/04/2015 : UMR_S 1034
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Classement scientifique ERC
- 2007 - 2010 : LS7- Prevention, Diagnosis and Treatment of Human Diseases : Medical technologies and tools for prevention, diagnosis and treatment of human diseases, therapeutic approaches and interventions, pharmacology, preventative medicine, epidemiology and public health, digital medicine
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Etablissements
- 2011 - 2013 : BORDEAUX 2- Université Victor Segalen Bordeaux 2
- 2011 - 2013 : CNRS- Centre national de la recherche scientifique
- 2007 - 2011 : BORDEAUX 2- Université Victor Segalen Bordeaux 2
- 2007 - 2011 : CNRS- Centre national de la recherche scientifique
- 2007 - 2010 : INSERM- Institut national de la sante et de la recherche medicale